Showing posts with label glutathione. Show all posts
Showing posts with label glutathione. Show all posts

Friday, June 17, 2011

Natural Ways to Help with ADD & Hyperactivity

This is an adaption by Kay Ness from the Willis list.

There are eight things that reverse inattention and hyperactivity every time.

A 2003 study listed these causes:
  1. Food and additive allergies
  2. Environmental toxicity
  3. Dietary deficiencies of protein
  4. Excess of simple sugars
  5. Mineral imbalances, particularly iron deficiency
  6. Deficiencies in cell membrane components (Fatty acids and Phospholipids)
  7. Thyroid disorders
  8. Deficiencies in B-vitamins

What to do:

First: NO sugar, fruit juices, aspartame (NutraSweet), Splenda, MSG, and limited and controlled amounts of High-Glycemic Indexed foods.

Second: NO Phosphates (meaning processed meats, soft drinks, prepared cakes and baked goods with phosphates/phosphoric acid or bromine added).

Third: eliminate all allergens.

Fourth: NO colors, dyes, or high salicylate foods (Feingold diet).

These four cost nothing, yet often solve the problem.

Fifth: supplement 100 mg Vitamin B6 (with 50 mg vitamin B2) both 3 times a day. This alone has proven more effective than Ritalin, with no side effects.

Sixth: supplement 50 mg zinc (at evening on empty stomach with a little oil) and supplement 100 mg magnesium 3 times a day. Always supplement 50 mg vitamin B1 three times a day with the magnesium.

Seventh: Introduce fatty acids into the diet: Evening Primrose Oil and cod-liver oil (DHA alone
will not work).

Eighth: Underneath all this place a good multivitamin/mineral.

Other supplements known to help with the hyperness are calcium, iron, chromium, boron, lithium orotate, folic acid, glutathione, the amino acid tyrosine (builds dopamine and the stimulating hormone norepinephrine), taurine and *GABA (calming amino acids), and Saccharomyces boulardii and colostrum to build Immunoglobulin-A (IgA) to overcome allergies.

Children with blood lead levels above 10 micrograms per deciliter were nearly three times as likely to show hyperactivity and anti-social behavior as children whose blood lead levels were between 0 and 2 micrograms per deciliter. Detoxifying lead naturally.

Kay says she'd add magnesium to the mix.
Chembalance.com addresses minerals and specific vitamin deficiencies that you can test yourself every day. Oh, I'd also look at iodine. I don't believe the 'every time' thing but certainly this is a good and basic list.

*Since DS causes an overexpression of GABA, I wouldn't supplement our kids with it, unless you know specifically that your child needs it. -Andi

Another article on treating ADD naturally found here: http://intelegen.com/nutrients/add.htm

ADD & ADHD

ADD & ADHD Natural Control of ADD & ADHD
Billie J. Sahley, Ph.D., CNC

In Toxic Psychiatry, Peter Breggin, MD states, Hyperactivity is the most frequent justification for drugging children. Difficult-to-control children are certainly not a new phenomenon, but attempts to give them a medical diagnosis are the product of modern psychology and psychiatry. At first, psychiatrists called hyperactivity a brain disease: minimal brain dysfunction (MBD). When no minimal brain dysfunction could be demonstrated, the label became attention deficit disorder (ADD).

Six million children in this country suffer some type of learning disability, ADD, or ADD with hyperactivity (ADHD). Over two million children currently take Ritalin for ADD/ADHD. ADD and ADHD may be caused by psychological problems, including trauma and abuse, nutritional deficiencies, chemical imbalances, allergic responses to food and chemicals, or a poor diet. A failure in the brains inhibitory system (the ability of the brain to inhibit and control itself) may also cause ADD/ADHD.

Ritalin, the most commonly used drug for ADD and ADHD, is an amphetamine and a Schedule II class drug (other Schedule II drugs are morphine, opium, and medicinal cocaine). Doctors prescribe Ritalin for many children who do not need it, causing a number of adverse mental and physical side effects. Yet this potent, toxic drug is being used as a quick fix to quiet children. Surprisingly, prescription rates for Ritalin doubled between 1992 and 1996.

Children demonstrating symptoms of anxiety, ADHD or ADD often have an imbalance in their brains biochemistry. A biochemical imbalance results from a deficiency of neurotransmitters, the chemical messengers of the brain. If a biochemical imbalance goes untreated, a child can display maladaptive behavior, followed by possible long-term physical and emotional problems.

A childs state of health reflects his or her state of nutrition. When minerals, vitamins, amino acids, enzymes, or even hormones are deficient in a childs system, the result can be a disturbed biochemical homeostasis causing impaired functions in the brain. This, in turn, can cause an inability to focus, concentrate, and stay on task.

At the Pain and Stress Center in San Antonio, we have successfully treated numerous children with orthomolecular therapy. Orthomolecular therapy corrects the brains biochemical imbalance, without toxic drugs that can produce adverse side effects. ADD/ADHD presents a major problem facing parents today. Most people think of hyperactivity as some type of behavioral problem (a child who is impatient, impulsive, and constantly moving); but not all hyperactive children are aggressive. Some are very passive, withdrawn, and find it hard to communicate their feelings.

ADD/ADHD is not a condition that can be measured in precise scientific terms. Nor is it a situation with a quick fix, especially with powerful and addictive drugs such as Ritalin. ADD/ADHD is a complex and intricate condition in which children demonstrate maladaptive or disorganized behaviors, which put them out of sync with the world around them.

Numerous clinical studies established that hyperactive children often have low serotonin levels. A proper combination of tryptophan or 5-HTP and B6, elevates the serotonin level and balances the brain; the childs symptoms diminish. The dosage, of course, depends on the childs age, weight, and the degree of hyperactivity.

Effectiveness of Amino Acids
Neurotransmitters affect behavior and learning. A neurotransmitter deficiency consequently has a dramatic effect on childrens or adults abilities to learn and function in an orderly manner. Most hyperactive and ADD children are born with a shortage of neurotransmitters, establishing a genetic link, most often on the male side. These children also do not manufacture the needed amount of these chemical messengers.

Where do we get neurotransmitters? From the amino acids, GABA, glycine, taurine, tyrosine, glutamine and tryptophan. Do children or adults get enough aminos through diet? NO! Balanced amino-acid doses, in the right combination and formulas, produce the needed neurotransmitters naturally. Using a stimulant medication to try to produce neurotransmitters is like a shotgun going off in the childs brain. Our children were not born with Ritalin in their brain, so how can they have a Ritalin deficiency?

Approximately fifty different neurotransmitters exist in the human brain, but communication between brain cells uses only ten (approximately) major neurotransmitters. How we feed the brain directly affects our production of neurotransmitters. With proper nutrition and supplementation, we can correct or enhance mind, mood, memory, and behavior.

All major neurotransmitters are made from amino acids and dietary protein. One of the dangers of a low-protein diet is not ingesting enough amino acids to make adequate brain neurotransmitters. Apathy, lethargy, difficulty concentrating, loss of interest, and insomnia all result when the diet does not include adequate amounts of amino acids. Drugs do not produce or increase production of neurotransmitters. Drugs only address symptoms. Amino acids restore the balance nature intended.

Some of the major symptoms of neurotransmitter deficiencies are ADD, ADHD, brain fog, mood swings, increased stress, anxiety, depression, insomnia, irritability, and aggression. Stress plays a major role in the depletion of neurotransmitters. Inhibitory neurotransmitters are the keys to behavior, emotions, and pain. Inhibitory amino acids include tryptophan, taurine, GABA, and glycine.

Millions of people have turned to drugs known as SSRIs (Selective Serotonin Reuptake Inhibitors). These drugs, such as Prozac, Paxil, Zoloft, and Effexor work by selective enhancement of serotonin levels. SSRIs prevent the presynaptic nerve from reabsorbing serotonin that it previously secreted. Prozac causes an increase in brain serotonin levels; but Prozac and other prescription drugs do not increase neurotransmitters. (See Figure 1).

5-HTP is synergistic with other supplements that enhance neurotransmitters such as GABA, glutamine, tyrosine, phenylalanine, and glycine. Magnesium prolongs the benefits of 5-HTP. Chronic stress depletes available serotonin, as well as interferes with serotonins ability to control behavior. Research demonstrates that low serotonin levels can change brain function and impair learning. Low serotonin may be responsible for an increase in depression and drug use among teens and children. Most teens with low serotonin levels are more prone to try recreational drugs or even prescription drugs, for relief. A low brain serotonin level impairs the ability to focus and reason. 5-HTP shows a lot of promise as a natural answer to a multitude of problems that plague adults and children. Use caution with 5-HTP if your child is taking prescription antidepressant medications.

GABA (Gamma-aminobutyric acid)
GABA, an inhibitory neurotransmitter, is found throughout the central nervous system. GABA assumes an ever-enlarging role as a significant influence on ADD, ADHD, stress, anxiety, and depression, as well as stress-induced illnesses. According to Candace Pert, a neuroscientist who discovered the GABA receptor, every cell in the body has a GABA receptor, which is one reason why GABA has such positive effects. GABA inhibits the cells from firing, diminishing anxiety-related messages.

Tranquilizers provide only temporary relief. We have seen many patients on Xanax that still experience anxiety. They have been told it is not addictive: it is! THERE IS NO SUCH THING AS A TRANQUILIZER DEFICIENCY! Nutrient deficiencies do occur, however; and they can and do change behavior. GABA, glutamine, and glycine prove vital for energy and the smooth running of brain functions. We have successfully used these three amino acids with patients to ease anxiety, irritability, and ADD.

Research demonstrates a large number of children who display ADD/ADHD behavior actually experience anxiety. If they use all available GABA, then the receptors in the brain become empty, allowing the brain to be bombarded with random firings of excitatory messages. However, when adequate amounts of GABA are present, the reception of multiple random firings are blocked, so the brain does not become overwhelmed. At the Pain & Stress Center we regularly combine GABA and other amino acids to achieve positive results. Dose amounts vary, depending on the age and weight of the child.

GABA now takes its place as a major influence on those taking drugs, and in many cases, replacing the drugs. We have found that, when combined with other amino acids, GABA works exceptionally well with ADD children.

L-Glutamine
Glutamine, along with GABA and Glycine, is rapidly becoming an important therapeutic amino acid of the 21st century. Glutamine, found in many foods, is the third most abundant amino acid in the blood and brain. It also provides a major alternative fuel source for the brain when blood sugar levels are low.

Glutamine functions as an inhibitory neurotransmitter, and is the precursor for GABA, the antianxiety amino acid. The amino acid trio of Glutamine, GABA, and Glycine plus B6 are among the major inhibitory neurotransmitters in the brain. Glutamine is found in the nerves of the hippocampus, the memory center of the brain, in the cranial nerves, and in many other areas of the brain. These three amino acids work together as inhibitory neurotransmitters. Anyone taking amino acids must take B6 to metabolize the amino acids.

Intellectually impaired children and adults often show an increase in IQ after taking glutamine in combination with Ginkgo biloba and B6. Dr. Roger Williams demonstrated that children and adults diagnosed with ADHD showed a marked improvement when taking 250 mg to 1,000 mg of glutamine daily.

GABA and glutamine are not only found in the brain, but also in the receptor sites throughout the body. Glutamine is the memory and concentration amino acid. Seventy five percent of hyperactive and ADD childrens blood tests showed low levels of glutamine.

Dr. C. Fredericks research also demonstrated a definite increase in the IQs of children given glutamine. When glutamine was given daily, children showed impressive improvements in their abilities to learn, to retain, and to recall. Glutamine is a major part of my orthomolecular program for hyperactive and ADHD children. Glutamine is one of the amino acids that create the neurotransmitters in the brain that enhance learning and memory. Hyperactive and ADD children have low neurotransmitter levels, especially glutamine. Adding glutamine increases the level of neurotransmitters. Start with 500 mg of glutamine and gradually increase until you reach the optimal dose for your child, to a maximum of 3,000 mg per day.

Taurine
Taurine is now classified as a conditionally essential amino acid in the adult. In infants and children, however, taurine is an essential amino acid. As one of the sulfur amino acids, adults synthesize taurine from cysteine and methionine, provided B6 and zinc are present. Taurine is found abundantly throughout the body in the heart, olfactory bulb, central nervous system, and brain (hippocampus and pineal gland).

As an inhibitory neurotransmitter, taurine, after GABA, is the second-most important inhibitory transmitter in the brain. Taurines inhibitory action in the brain equals that of GABA and glycine. Its inhibitory effect is one source of taurines anticonvulsant and antianxiety properties.

Some children with Downs syndrome have shown an increase in IQ levels when taurine was added to their diet along with glutamine, B6, and vitamin E. The need for taurine increases whenever you experience more stress than usual, or have an illness.

Tyrosine
Tyrosine is the amino acid and inhibitory neurotransmitter that often helps overcome depression. Clinical studies show that tyrosine controls medication-resistant depression.

In a 1980 issue of the American Journal of Psychiatry, a study by Dr. Alan Gelenberg of Harvard Medical School discussed the role of tyrosine in the control of anxiety and depression. Dr. Gelenberg postulated that the lack of available tyrosine results in deficiency of the hormone norepinephrine at a specific location in the brain that relates to mood problems such as depression. Children given tyrosine supplementation demonstrated a marked improvement in mental performance and mood stability.

Tyrosine, because of its role in assisting the body to cope physiologically with stress and building the bodys natural store of adrenaline, deserves to be called the stress amino acid. Stress exhaustion requires tyrosine. During periods of stress, in order to continue coping with stress physiologically, the brain requires tyrosine. Tyrosine aids children and young teens, as well as adults, with recurrent depression and mood disorders. In children, dosage ranges from 200 to 500 mg daily.

Glycine
Glycine is a nonessential amino acid, with the simplest structure of all the amino acids resembling glucose (blood sugar) and glycogen (excess sugar converted in the liver for storage). Glycine is sweet to the taste, can be used as a sweetener, and can mask bitterness and saltiness. Pure glycine dissolves readily in water. As the third major inhibitory neurotransmitter in the brain, glycine readily passes the blood-brain barrier. Studies by the late Carl Pfeiffer, MD, Ph.D., demonstrated glycine as an important factor in psychiatric disorders.

Glycine decreases the craving for sugar, and, in many cases, can replace sugar on foods such as cereal. Glycine calms aggression in both children and adults. When combined with GABA and glutamine, glycine influences brain function by slowing down anxiety-related messages from the limbic system.

As a very nontoxic amino acid, both children and adults can use glycine. Glycine can be mixed with other amino acids. Doses for a child range between 500 to 2,000 mg daily, divided.

Magnesium
Hyperactive or ADD children are almost always deficient in magnesium. Magnesium proves necessary for proper brain energy and is the first mineral depleted when anyone (child or adult) is under stress. Magnesium is a stress mineral, and deficiency can lead to hyperactive or ADD behavior.

Magnesium plays a significant role in sugar metabolism and in the proper utilization of carbohydrates to create energy. Magnesium is so very important in a childs diet, especially if he displays hyperactive behavior, ADD, or other behavioral problems. Magnesium can be taken in liquid form, tablet, or capsule.

When added to the ADD/ADHD diet, calming effects sometimes occur immediately. Most magnesium exists inside the cells where it activates enzymes necessary for the metabolism of carbohydrates and amino acids. In 1988, a study published in Alternative Medicine Review linked the development of ADHD to low blood-serum magnesium levels. A group of children followed for six months were given 200 mg of magnesium a day. Researchers noted remarkably decreased hyperactivity in the children.

As a major nutrient needed by ADD/ADHD children and adults, magnesium is the number one stress mineral needed by the body. Magnesium is responsible for over three hundred enzyme functions. It cannot be stored by the body, and it must be taken daily. Symptoms of magnesium deficiency include asthma, migraines, eye twitches, anxiety, confusion, muscle spasms, irritability, depression, nervousness, fatigue, mood swings, PMS, hypertension, and insomnia.

Calcium
A calcium deficiency can also induce ADD/ADHD behavior. A child deficient in calcium exhibits irritability, sleep disturbances, anger, and inattentiveness. The first signs of a calcium deficiency include nervous stomach, cramps, tingling in the arms and legs, and painful joints. A calcium deficiency can also lead to ADD/ADHD behavior. Children sensitive to dairy products must receive daily calcium supplementation in capsule, chewable, or liquid form. Children up to 10 years of age need 1000 mg of calcium daily; adolescents need 1,200 to 1,500 mg daily. For those involved in sports activities, calcium supplementation is a must.

Huperzine
Recent research reports that Huperzine A improves mental function and learning in adolescents. Chinese researchers designed a study to determine the efficiency of Huperzine on memory and learning. The clinical study included 34 matched pairs of junior middle school students that had significant complaints of poor memory and difficulty in learning. In the double blind trial, half of the students received a placebo while the other half received Huperzine A for four weeks. Academic performance was measured before and after the clinical trial. The Huperzine group scored significantly better on standard memory tests without side effects.

Huperzine A is an extract derived from Chinese club moss. Huperzine can be combined with amino acids and other nutrients. The suggested dosage is one 50 mcg capsule in the morning and in the evening for children aged 12 and over.

This information is excerpted from my book Control Hyperactivity/ADD Naturally. Other resources include Is Ritalin Necessary?

Both are available through:

Pain & Stress Center
5282 Medical Dr. #160
San Antonio, TX 78229-6023


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Thursday, April 7, 2011

Why Milk Thistle?

"this article is important because studies have shown that people w/Ds (and people w/autism)
have low levels of glutathione. .which is a problem, because low levels of glutathione can be a factor in decreased immunity..PLUS, the liver needs glutathione in order to break down acetominophen (tylenol) and other toxins.
http://aaemonline. org/blog/ category/ glutathione/ (for more information, read the section 'a mathmatical model of glutathione metabolism)"

Milk thistle increases the production of glutathione.

Overview:

Milk thistle (Silybum marianum) has been used for 2,000 years as an herbal remedy for a variety of ailments, particularly liver and gall bladder problems. Several scientific studies suggest that substances in milk thistle (especially a flavonoid called silymarin) protect the liver from toxins, including certain drugs such as acetaminophen (Tylenol), which can cause liver damage in high doses. Silymarin has antioxidant and anti-inflammatory properties, and it may help the liver repair itself by growing new cells.

Although a number of animal studies demonstrate that milk thistle can be helpful in protecting the liver, results in human studies are mixed.

Liver disease from alcohol

Milk thistle is often suggested as a treatment for alcoholic hepatitis and alcoholic cirrhosis. But scientific studies show mixed results. Most studies show milk thistle improves liver function and increases survival in people with cirrhosis or chronic hepatitis. But problems in the design of the studies (such as small numbers of participants and differences in dosing and duration of milk thistle therapy) make it hard to draw any real conclusions.

Viral hepatitis

Milk thistle is widely used in the treatment of viral hepatitis (particularly hepatitis C). But studies show mixed results. Some found improvements in liver function, while others did not. None of the studies compared milk thistle with interferon or other medications for viral hepatitis.

Mushroom poisoning

Based on traditional use, milk thistle has been used as an emergency antidote to poisoning by deathcap mushroom (Amanita phalloides). Animal studies have found that milk thistle extract completely counteracts the toxic effects of the mushroom when given within 10 minutes of ingestion. If given within 24 hours, it significantly reduces the risk of liver damage and death.

Cancer

Early laboratory studies also suggest that silymarin and other active substances in milk thistle may have anti-cancer effects. These substances appear to stop cancer cells from dividing and reproducing, shorten their life span, and reduce blood supple to tumors. More studies are needed, however, to show whether milk thistle has any effects in the body (not just test tubes).

Plant Description:

Milk thistle is native to the Mediterranean region, and is now found throughout the world. This stout thistle usually grows in dry, sunny areas. The spiny stems branch at the top, and reach a height of 4 to 10 feet. The leaves are wide, with white blotches or veins. Milk thistle gets its name from the milky white fluid that comes from the leaves when they are crushed. The flowers are red-purple. The small, hard-skinned fruit is brown, spotted, and shiny. Milk thistle spreads quickly (it is considered a weed in some parts of the world), and it matures quickly, in less than a year.

What's It Made Of?:

The active ingredient -- the one that protects the liver -- in milk thistle is known as silymarin. Silymarin is actually a group of flavonoids (silibinin, silidianin, and silicristin), which are thought to help repair liver cells damaged by alcohol and other toxic substances. Silymarin also keeps new liver cells from being destroyed by these same toxins. It reduces inflammation (which is why it is often suggested for people with liver inflammation or hepatitis), and is a strong antioxidant.

Most milk thistle products are standardized preparations made from the seeds of the plant. Most preparations are standardized to contain 70 - 80% of silymarin.

Available Forms:

  • Capsules of standardized dried herb (each capsule contains about 120 - 140 mg silymarin)
  • Liquid extract
  • Tincture
  • Silymarin phosphatidylcholine complex

A few studies show that a silymarin-phosphatidylcholine complex may be absorbed more easily than regular standardized milk thistle. Phosphatidylcholine is a key element in cell membranes. It helps silymarin attach easily to cell membranes, which may keep toxins from getting inside liver cells. Alcohol extracts should be avoided by anyone with alcohol-related liver disease.

How to Take It

Adult

If you think you have a liver problem, you should see a doctor. Liver disease can be life threatening.

  • Recommended dose: 280 - 450 mg per day in divided doses or silymarin-phosphatidylcholine complex 100 - 200 mg two times per day.

Pediatric

There are no studies showing whether or not it is safe to give milk thistle to a child. Liver problems can be serious and should be diagnosed by a physician. Talk to your doctor before giving milk thistle to a child.

I figure dosage for Jett this way:

adult 280 - 450 mg a day/140 lbs

140 - 225 mg a day/70 lbs

70 - 112 mg a day/35 lbs

35 -56 mg a day/17 lbs, one drop in the morning and one drop later in the day

Products

I use http://www.vitacost.com/Natures-Answer-Milk-Thistle-Seed

35.7 mg per drop

Precautions:

The use of herbs is a time-honored approach to strengthening the body and treating disease. Herbs, however, can trigger side effects and can interact with other herbs, supplements, or medications. For these reasons, herbs should be taken with care, under the supervision of a health care practitioner.

Milk thistle is generally regarded as safe. Side effects are usually mild and may involve stomach upset and diarrhea. Some people may get a rash from touching milk thistle plants.

Milk thistle should not be used by pregnant or breastfeeding women.

People with a history of hormone-related cancers, including breast and uterine cancer and prostate cancer, should not take milk thistle.

Possible Interactions:

If you are currently being treated with any of the following medications, you should not use milk thistle without first talking to your healthcare provider.

  • Antipsychotics -- includes butyrophenones (such as haloperidol) and phenothiazines (such as chlorpromazine, fluphenazine, and promethazine)
  • Phenytoin(Dilantin) -- a medication used for seizures
  • Halothane -- a medication used during general anesthesia

Milk thistle may interfere with the following medications, because both milk thistle and these medications are broken down by the same liver enzymes:

  • Allergy drugs -- such as fexofenadine (Allegra)
  • Drugs for high cholesterol -- including statins such as lovastatin (Mevacor, Altocor)
  • Anti-anxiety drugs -- including alprazolam (Xanax), diazepam (Valium), and lorazepam (Ativan)
  • Antiplatelet and anticoagulant drugs (blood thinners) -- including clopidogrel (Plavix) and warfarin (Coumadin)
  • Some cancer drugs

Alternative Names:

Silybum marianum; St. Mary's thistle

  • Reviewed last on: 3/22/2009
  • Steven D. Ehrlich, NMD, private practice specializing in complementary and alternative medicine, Phoenix, AZ. Review provided by VeriMed Healthcare Network.

Supporting Research

Agarwal R, Agarwal C, Ichikawa H, Singh RP, Aggarwal BB. Anticancer potential of silymarin: from bench to bed side. Anticancer Res. 2006 Nov-Dec;26(6B):4457-98. Review.

Agency for Healthcare Research and Quality. Milk thistle: effects on liver disease and cirrhosis and clinical adverse effects. Summary, evidence report/technology assessment: number 21, September 2000.

Asghar Z, Masood Z. Evaluation of antioxidant properties of silymarin and its potential to inhibit peroxyl radicals in vitro. Pak J Pharm Sci. 2008 Jul;21(3):249-54.

Barve A, Khan R, Marsano L, Ravindra KV, McClain C. Treatment of alcoholic liver disease. Ann Hepatol. 2008 Jan-Mar;7(1):5-15. Review.

Blumenthal M, Goldberg A, Brinckmann J. Herbal Medicine: Expanded Commission E Monographs. Newton, MA: Integrative Medicine Communications; 2000:257-263.

Ferenci P, Scherzer TM, Kerschner H, Rutter K, Beinhardt S, Hofer H, et al. Silibinin is a potent antiviral agent in patients with chronic hepatitis C not responding to pegylated interferon/ribavirin therapy. Gastroenterology. 2008 Nov;135(5):1561-7.

Gazak R, Walterova D, Kren V. Silybin and silymarin -- new and emerging applications in medicine. Curr Med Chem. 2007;14(3):315-38. Review.

Giese LA. A study of alternative health care use for gastrointestinal disorders. Gastroenterol Nurs. 2000;23(1):19-27.

Gordon A, Hobbs DA, Bowden DS, Bailey MJ, Mitchell J, Francis AJ, Roberts SK. Effects of Silybum marianum on serum hepatitis C virus RNA, alanine aminotransferase levels and well-being in patients with chronic hepatitis C. J Gastroenterol Hepatol. 2006 Jan;21(1 Pt 2):275-80.

Hoh C, Boocock D, Marczylo T, Singh R, Berry DP, Dennison AR, et al. Pilot study of oral silibinin, a putative chemopreventive agent, in colorectal cancer patients: silibinin levels in plasma, colorectum, and liver and their pharmacodynamic consequences. Clin Cancer Res. 2006 May 1;12(9):2944-50.

Jiang C, Agarwal R, Lu J. Anti-angiogenic potential of a cancer chemopreventive flavonoid antioxidant, Silymairn: inhibition of key attributes of vascular endothelial cells and angiogenic cytokine secretion by cancer epithelial cells. Biochem Biophys Res Commun. 2000;276:371-378.

Köksal E, Gülçin I, Beyza S, Sarikaya O, Bursal E. In vitro antioxidant activity of silymarin. J Enzyme Inhib Med Chem. 2009 Apr;24(2):395-405.

Low Dog T. Traditional and alternative therapies for breast cancer. Altern Ther Health Med. 2001;7(3):36-47.

Mayer KE, Myers RP, Lee SS. Silymarin treatment of viral hepatitis: a systematic review. J Viral Hepat. 2005 Nov;12(6):559-67. Review.

Najm W, Lie D. Dietary supplements commonly used for prevention. Prim Care. 2008 Dec;35(4):749-67.

Rainone F. Milk thistle. Am Fam Physician. 2005 Oct 1;72(7):1285-8. Review.

Ramasamy K, Agarwal R. Multitargeted therapy of cancer by silymarin. Cancer Lett. 2008 Oct 8;269(2):352-62. Review.

Rambaldi A, Jacobs BP, Iaquinto G, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C liver diseases – a systematic cochrane hepato-biliary group review with meta-analyses of randomized clinical trials. Am J Gastroenterol. 2005 Nov;100(11):2583-91. Review.

Rotblatt M, Ziment I. Evidence-Based Herbal Medicine. Philadelphia, PA: Hanley & Belfus, Inc; 2002:266-271.

Saller R, Brignoli R, Melzer J, Meier R. An updated systematic review with meta-analysis for the clinical evidence of silymarin. Forsch Komplementmed. 2008 Feb;15(1):9-20. Review.

Zielinska-Przyjemska M, Wiktorowicz K. An in vitro study of the protective effect of the flavonoid silydianin against reactive oxygen species. Phytother Res. 2006 Feb;20(2):115-9

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Glutathione: The Mother of All Antioxidants

by Mark Hyman, M.D.

from a href="http://www.huffingtonpost.com/dr-mark-hyman/glutathione-the-mother-of_b_530494.html" target="_blank" rel="nofollow">http://www.huffingt onpost.com/ dr-mark-hyman/ glutathione- the-mot...>

It's the most important molecule you need to stay healthy and prevent disease -- yet you've probably never heard of it. It's the secret to prevent aging, cancer, heart disease, dementia and more, and necessary to treat everything from autism to Alzheimer's disease. There are more than 89,000 medical articles about it -- but your doctor doesn't know how address the epidemic deficiency of this critical life-giving molecule ...

What is it? I'm talking about the mother of all antioxidants, the master detoxifier and maestro of the immune system: GLUTATHIONE (pronounced "gloota-thigh- own").

The good news is that your body produces its own glutathione. The bad news is that poor diet, pollution, toxins, medications, stress, trauma, aging, infections and radiation all deplete your glutathione.

This leaves you susceptible to unrestrained cell disintegration from oxidative stress, free radicals, infections and cancer. And your liver gets overloaded and damaged, making it unable to do its job of detoxification.

In treating chronically ill patients with Functional Medicine for more than 10 years, I have discovered that glutathione deficiency is found in nearly all very ill patients. These include people with chronic fatigue syndrome, heart disease, cancer, chronic infections, autoimmune disease, diabetes, autism, Alzheimer's disease, Parkinson's disease, arthritis, asthma, kidney problems, liver disease and more.

At first I thought that this was just a coincidental finding, but over the years I have come to realize that our ability to produce and maintain a high level of glutathione is critical to recovery from nearly all chronic illness -- and to preventing disease and maintaining optimal health and performance. The authors of those 76,000 medical articles on glutathione I mentioned earlier have found the same thing!

So in today's blog I want to explain what glutathione is, why it's important and give you 9 tips that will help you optimize your glutathione levels, improve your detoxification system and protect help yourself from chronic illness.

What is Glutathione?

Glutathione is a very simple molecule that is produced naturally all the time in your body. It is a combination of three simple building blocks of protein or amino acids -- cysteine, glycine and glutamine.

The secret of its power is the sulfur (SH) chemical groups it contains. Sulfur is a sticky, smelly molecule. It acts like fly paper and all the bad things in the body stick onto it, including free radicals and toxins like mercury and other heavy metals.

Normally glutathione is recycled in the body -- except when the toxic load becomes too great. And that explains why we are in such trouble ...

In my practice, I test the genes involved in glutathione metabolism. These are the genes involved in producing enzymes that allow the body to create and recycle glutathione in the body. These genes have many names, such as GSTM1, GSTP1 and more.

These genes impaired in some people for a variety of important reasons. We humans evolved in a time before the 80,000 toxic industrial chemicals found in our environment today were introduced into our world, before electromagnetic radiation was everywhere and before we polluted our skies, lakes, rivers, oceans and teeth with mercury and lead.

That is why most people survived with the basic version of the genetic detoxification software encoded in our DNA, which is mediocre at ridding the body of toxins. At the time humans evolved we just didn't need more. Who knew we would be poisoning ourselves and eating a processed, nutrient-depleted diet thousands of years later?

Because most of us didn't require additional detoxification software, almost of half of the population now has a limited capacity to get rid of toxins. These people are missing GSTM1 function -- one of the most important genes needed in the process of creating and recycling glutathione in the body.

Nearly all my very sick patients are missing this function. The one-third of our population that suffers from chronic disease is missing this essential gene. That includes me. Twenty years ago I became mercury poisoned and suffered from chronic fatigue syndrome due to this very problem. My GSTM1 function was inadequate and I didn't produce enough glutathione as a result. Eventually, my body broke down and I became extremely ill ...

This is the same problem I see in so many of my patients. They are missing this critical gene and they descend into disease as a result. Let me explain how this happens ...

The Importance of Glutathione in Protecting Against Chronic Illness

Glutathione is critical for one simple reason: It recycles antioxidants. You see, dealing with free radicals is like handing off a hot potato. They get passed around from vitamin C to vitamin E to lipoic acid and then finally to glutathione which cools off the free radicals and recycles other antioxidants. After this happens, the body can "reduce" or regenerate another protective glutathione molecule and we are back in business.

However, problems occur when we are overwhelmed with too much oxidative stress or too many toxins. Then the glutathione becomes depleted and we can no longer protect ourselves against free radicals, infections, or cancer and we can't get rid of toxins. This leads to further sickness and soon we are in the downward spiral of chronic illness.

But that's not all. Glutathione is also critical in helping your immune system do its job of fighting infections and preventing cancer. That's why studies show that it can help in the treatment of AIDS.(i)

Glutathione is also the most critical and integral part of your detoxification system. All the toxins stick onto glutathione, which then carries them into the bile and the stool -- and out of your body.

And lastly, it also helps us reach peak mental and physical function. Research has shown that raised glutathione levels decrease muscle damage, reduce recovery time, increase strength and endurance and shift metabolism from fat production to muscle development.

If you are sick or old or are just not in peak shape, you likely have glutathione deficiency.
In fact, the top British medical journal, the Lancet, found the highest glutathione levels in healthy young people, lower levels in healthy elderly, lower still in sick elderly and the lowest of all in the hospitalized elderly. (ii)

Keeping yourself healthy, boosting your performance, preventing disease and aging well depends on keeping your glutathione levels high. I'll say it again ... Glutathione is so important because it is responsible for keeping so many of the keys to UltraWellness optimized.

It is critical for immune function and controlling inflammation. It is the master detoxifier and the body's main antioxidant, protecting our cells and making our energy metabolism run well.

And the good news is that you can do many things to increase this natural and critical molecule in your body. You can eat glutathione- boosting foods. You can exercise. And you can take glutathione- boosting supplements. Let's review more specifics about each.

9 Tips to Optimize your Glutathione Levels

These 9 tips will help you improve your glutathione levels, improve your health, optimize your performance and live a long, healthy life.

Eat Foods that Support Glutathione Production

1. Consume sulfur-rich foods. The main ones in the diet are garlic, onions and the cruciferous vegetables (broccoli, kale, collards, cabbage, cauliflower, watercress, etc.).

2. Try bioactive whey protein. This is great source of cysteine and the amino acid building blocks for glutathione synthesis. As you know, I am not a big fan of dairy. But this is an exception -- with a few warnings. The whey protein MUST be bioactive and made from non-denatured proteins ("denaturing" refers to the breakdown of the normal protein structure). Choose non-pasteurized and non-industrially produced milk that contains no pesticides, hormones, or antibiotics. Immunocal is a prescription bioactive non-denatured whey protein that is even listed in the Physician's Desk Reference.

Exercise for Your Way to More Glutathione

3. Exercise boosts your glutathione levels and thereby helps boost your immune system, improve detoxification and enhance your body's own antioxidant defenses. Start slow and build up to 30 minutes a day of vigorous aerobic exercise like walking or jogging, or play various sports. Strength training for 20 minutes 3 times a week is also helpful.

Take Glutathione Supporting Supplements

One would think it would be easy just to take glutathione as a pill, but the body digests protein -- so you wouldn't get the benefits if you did it this way. However, the production and recycling of glutathione in the body requires many different nutrients and you CAN take these. Here are the main supplements that need to be taken consistently to boost glutathione. Besides taking a multivitamin and fish oil, supporting my glutathione levels with these supplements is the most important thing I do every day for my personal health.

4. N-acetyl-cysteine. This has been used for years to help treat asthma and lung disease and to treat people with life-threatening liver failure from Tylenol overdose. In fact, I first learned about it in medical school while working in the emergency room. It is even given to prevent kidney damage from dyes used during x-ray studies.

5. Alpha lipoic acid. This is a close second to glutathione in importance in our cells and is involved in energy production, blood sugar control, brain health and detoxification. The body usually makes it, but given all the stresses we are under, we often become depleted.

6. Methylation nutrients (folate and vitamins B6 and B12). These are perhaps the most critical to keep the body producing glutathione. Methylation and the production and recycling of glutathione are the two most important biochemical functions in your body. Take folate (especially in the active form of 5 methyltetrahydrofol ate), B6 (in active form of P5P) and B12 (in the active form of methylcobalamin) .

7. Selenium. This important mineral helps the body recycle and produce more glutathione.

8. A family of antioxidants including vitamins C and E (in the form of mixed tocopherols) , work together to recycle glutathione.

9. Milk thistle (silymarin) has long been used in liver disease and helps boost glutathione levels.

So use these nine tips and see how they work to help you optimzie your glutathione levels. When you do, you will take one more step to lifelong vibrant health.


References

(i) De Rosa SC, Zaretsky MD, Dubs JG, Roederer M, Anderson M, Green A, Mitra D, Watanabe N, Nakamura H, Tjioe I, Deresinski SC, Moore WA, Ela SW, Parks D, Herzenberg LA, Herzenberg LA. N-acetylcysteine replenishes glutathione in HIV infection. Eur J Clin Invest. 2000 Oct;30(10):915- 29

(ii) Nuttall S, Martin U, Sinclair A, Kendall M. 1998. Glutathione: in sickness and in health. The Lancet 351(9103):645- 646

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